GPIIIa (HPA1a/b, L33P)

Service Description

PCR-Hybridization: Glycoprotein Polymorphism (GPIIIa ) is a protein found on the surface of platelets that is involved in platelet aggregation and clot formation. The HPA1a/b polymorphism, also known as L33P, is a common genetic variation in the GPIIIa gene that results in the substitution of proline (Pro) for leucine (Leu) at position 33 of the protein. The HPA1a/b polymorphism has been associated with increased platelet activation and aggregation, which may contribute to an increased risk of thrombotic events such as myocardial infarction, stroke, and venous thromboembolism. However, the evidence for this association is not consistent across all studies, and other factors such as age, sex, and other genetic and environmental factors may also play a role. Testing for the HPA1a/b polymorphism may be useful in identifying individuals who may be at increased risk of thrombotic events, particularly in the context of other risk factors such as smoking, obesity, or a family history of cardiovascular disease. Sample: BLOOD Results:2 weeks Phlebotomy fee: £15 (included in price)